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. 2020 Sep 24;252(3):e5517. doi: 10.1002/path.5517

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© 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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ADAM10 regulates Notch expression and promotes cell proliferation and migration in human 293T cells. (A, B) Effect of pcDNA3‐ADAM10‐HA plasmid on the protein levels of NOTCH1 (NTM), NOTCH2 (NTM), and HES1 (n = 6). (C–E) Immunofluorescence staining for NOTCH1 and NOTCH2 in 293T cells. The ratio of nuclear expression to total expression was analyzed using Imaris software (n = 3). Scale bars: 5 μm. (F, G) Effect of pcDNA3‐ADAM10‐HA plasmid on the cell proliferation index and migration index of 293T cells. (H, I) Effect of siRNA‐ADAM10 and siRNA‐ADAM17 on cell proliferation and migration of 293T cells.