Figure 3.

a) Formation of camouflaged tissue PA composed of tissue-PA-low molecular-weight heparin (t-PA-LMWH) and HSA protamine-targeting peptide. b) The linkage of albumin with tissue plasminogen activator serves as a steric barrier to blood plasma protein. c) Binding of peptide-GP IIb/IIIa (expressed on the activated platelets surface) to the thrombus leads to complex deposition on the activated platelet surface. d) Administering heparin after the complex has accumulated at the thrombus region. e) Provoked release of t-PA and fibrinolysis. Redrawn from Ref ^[52].