Table 1. Allele Frequencies of Variant CYP2C19 and CYP2D6 Genes Among Different Populations Worldwidea.
| Genotype-based phenotype by metabolism category | Population, % | ||||
|---|---|---|---|---|---|
| European | African | East Asian | South Asian | Admixed American | |
| CYP2C19 | |||||
| PM | 3.3 | 3.3 | 14.2 | 11.8 | 1.1 |
| IM | 21.7 | 21.2 | 45.8 | 35.8 | 16.0 |
| PM plus IM | 25.0 | 24.6 | 60.1 | 47.6 | 17.1 |
| NM | 43.4 | 42.5 | 38.1 | 36.4 | 62.8 |
| UM | 31.6 | 32.9 | 1.8 | 16.0 | 20.1 |
| CYP2D6 | |||||
| PM | 6.2 | 2.8 | 0.7 | 2.1 | 3.8 |
| IM | 2.6 | 24.5 | 48.6 | 10.0 | 2.6 |
| PM plus IM | 8.8 | 27.3 | 49.3 | 12.2 | 6.4 |
| NM | 88.1 | 64.7 | 49.6 | 85.9 | 91.4 |
| UM | 3.2 | 8.0 | 1.2 | 1.9 | 2.2 |
Abbreviations: IM, intermediate metabolizer; NM, normal metabolizer; PM, poor metabolizer; UM, ultrarapid metabolizer.
a
Data are based on Zhou et al.9 Notable variations also exist within the global regions.