Table 3. Detailed Statistical Report of the Association of Metabolism Status With Antipsychotic and Antidepressant Exposure.

Drug	Enzyme	No. of studies	No. of patients by metabolism group		RoM (95% CI)	P value	I2 value, %
			Reference	Comparator
Antipsychotics
Aripiprazole	CYP2D6	5	693 NM	90 PM	1.51 (1.38-1.65)	<.001	0
	CYP2D6	9	664 NM	134 IM	1.47 (1.38-1.57)	<.001	65
	CYP2D6	12	814 NM	224 PM plus IM	1.48 (1.41-1.56)	<.001	56
Clozapine	CYP2D6	1	22 NM	4 PM	1.00 (0.43-2.32)	>.99	NA
	CYP2D6	2	33 NM	15 IM	1.22 (0.79-1.88)	.51	0
	CYP2C19	2	70 NM	8 PM	1.92 (1.32-2.79)	.008	0
	CYP2C19	4	127 NM	65 IM	1.00 (0.84-1.19)	.84	10
Haloperidol	CYP2D6	4	267 NM	46 PM	1.68 (1.40-1.91)	<.001	21
	CYP2D6	9	265 NM	158 IM	1.14 (1.05-1.25)	.003	0
Quetiapine	CYP2D6	1	171 NM	20 PM	1.32 (1.10-1.58)	<.001	NA
Risperidone	CYP2D6	13	937 NM	172 PM	1.40 (1.30-1.50)	<.001	17
	CYP2D6	11	469 NM	186 IM	1.31 (1.20-1.43)	<.001	44
	CYP2D6	23	1134 NM	358 PM plus IM	1.36 (1.28-1.44)	<.001	34
Antidepressants
Amitriptyline	CYP2D6	1	17 NM	4 PM	1.04 (0.65-1.68)	.86	NA
	CYP2D6	2	26 NM	9 IM	1.50 (1.23-1.84)	<.001	0
	CYP2C19	1	4 NM	6 PM	1.07 (0.81-1.41)	.58	NA
	CYP2C19	1	30 NM	18 IM	1.06 (0.89-1.25)	.50	NA
Escitalopram	CYP2C19	4	1110 NM	152 PM	2.63 (2.40-2.89)	<.001	84
	CYP2C19	4	1110 NM	760 IM	1.38 (1.28-1.48)	<.001	86
Fluvoxamine	CYP2D6	6	74 NM	72 IM	1.52 (1.23-1.89)	<.001	0
	CYP2C19	1	6 NM	6 IM	0.87 (0.31-2.45)	.77	NA
	CYP2C19	1	6 NM	6 PM	0.90 (0.31-2.65)	.84	NA
Fluoxetine	CYP2D6	1	8 NM	3 PM	2.26 (1.68-2.83)	<.001	NA
	CYP2C19	1	4 NM	6 PM	2.94 (2.36-3.67)	<.001	NA
	CYP2C19	2	71 NM	27 IM	1.48 (1.24-1.76)	<.001	13
Mirtazapine	CYP2D6	4	125 NM	19 PM	1.39 (1.23-1.57)	<.001	64
	CYP2D6	1	17 NM	14 IM	1.51 (1.20-1.91)	.010	NA
Nortriptyline	CYP2D6	1	5 NM	4 PM	3.32 (2.08-5.29)	<.001	NA
	CYP2D6	3	23 NM	14 IM	2.36 (2.10-2.65)	<.001	74
Paroxetine	CYP2D6	2	62 NM	11 PM	5.13 (3.82-6.87)	<.001	85
	CYP2D6	3	27 NM	14 IM	3.50 (2.52-4.85)	<.001	0
Sertraline	CYP2C19	3	565 NM	352 IM	1.38 (1.27-1.51)	<.001	0
	CYP2C19	2	537 NM	40 PM	2.70 (2.15-3.39)	<.001	0
Venlafaxine	CYP2D6	6	486 NM	120 PM	1.18 (1.04-1.33)	.01	50
	CYP2D6	3	436 NM	87 IM	1.14 (1.03-1.26)	.009	70
	CYP2D6	8	509 NM	207 PM plus IM	1.19 (1.09-1.29)	<.001	40
	CYP2C19	1	422 NM	21 PM	2.13 (1.54-2.93)	<.001	NA
	CYP2C19	1	422 NM	247 IM	1.19 (1.11-1.31)	<.001	NA

Abbreviations: IM, intermediate metabolizer; NA, not applicable; NM, normal metabolizer; PM, poor metabolizer; RoM, ratio of means.