Figure 4.

Schematic representation of the possible roles for RORA in migraine pathogenesis. RORA may contribute to migraine susceptibility as well as some symptoms with different mechanisms as follows: (i) affecting the expression of IL‐17 in Th17 and mast cells suggesting a pro‐inflammatory role; (ii) regulation of inflammation, neurodegeneration, and circadian rhythms via the mediation of melatonin effect; and (iii) affecting the circadian rhythms through the regulatory role of BMAL1 and REV‐ERB on its expression