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. 2020 Nov 27;477(22):4425–4441. doi: 10.1042/BCJ20200656

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© 2020 The Author(s)

This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). Open access for this article was enabled by the participation of University of Edinburgh in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC.

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Figure 5. — (A) Mean average TPM values for each group of FANTOM-5 samples were compared for each isoform. Certain tissues contain more PFK transcripts than other tissues e.g. renal, endothelium, and eye. Proportions of each isoform follow the general hierarchy of PFK-P > PFK-L > PFK-M, though with notable exceptions e.g. immune cells and skeletal muscle. Liver data are included under ‘Gut’ heading, and shows: 47.2% PFK-L; 47.1% PFK-P; 5.6% PFK-M. (B,C) PFK-P transcription overtakes PFK-L in monocyte-derived macrophages exposed to LPS (Panel B) and Influenza A (Panel C), with PFKFB3 correlating with PFK-P. PFK-M (blue squares with solid lines); PFK-L (red circles with dotted lines); PFK-P (green triangles with dashed lines); PFKFB3 (orange diamonds with dot-dashed lines). Lines are segmented lines of best fit, errors bars are standard deviations, n = 3 for LPS and n = 4 for influenza.

Inline graphic — (A) Mean average TPM values for each group of FANTOM-5 samples were compared for each isoform. Certain tissues contain more PFK transcripts than other tissues e.g. renal, endothelium, and eye. Proportions of each isoform follow the general hierarchy of PFK-P > PFK-L > PFK-M, though with notable exceptions e.g. immune cells and skeletal muscle. Liver data are included under ‘Gut’ heading, and shows: 47.2% PFK-L; 47.1% PFK-P; 5.6% PFK-M. (B,C) PFK-P transcription overtakes PFK-L in monocyte-derived macrophages exposed to LPS (Panel B) and Influenza A (Panel C), with PFKFB3 correlating with PFK-P. PFK-M (blue squares with solid lines); PFK-L (red circles with dotted lines); PFK-P (green triangles with dashed lines); PFKFB3 (orange diamonds with dot-dashed lines). Lines are segmented lines of best fit, errors bars are standard deviations, n = 3 for LPS and n = 4 for influenza.