Table 3.

test set validation statistical significance using different scores. A. Rank normalized score (pairwise; Wilcoxon matched-pairs signed rank test), B. Rank normalized score (Unpaired Comparison; Mann-Whitney U test), C. ΔRNS (Unpaired Comparison; Mann-Whitney U test). Assay Central (AC); AdaBoost (ada); Bernoulli Naïve-Bayes (bnb); k-nearest neighbors (knn); Random Forest (rf); support vector classification (svc); Deep Neural Networks (DL).

A.
	ada	bnb	DL	knn	rf	svc	Consensus	AC
ada	N/A	0.0006***	0.1011	0.5457	0.1688	0.0894	0.0340*	0.0164*
bnb	0.0006***	N/A	0.0004***	0.0491*	0.0035**	0.0008***	<0.0001****	0.9888
DL	0.1011	0.0004***	N/A	0.0291*	0.0425*	0.5088	0.9218	0.0002***
knn	0.5457	0.0491*	0.0291*	N/A	0.2768	0.0526	0.0457*	0.0526
rf	0.1688	0.0425*	0.0035**	0.2768	N/A	0.0039**	0.0011**	0.2076
svc	0.0894	0.0008***	0.5088	0.0526	0.0039**	N/A	0.5457	0.0008***
Consensus	0.0340*	<0.0001****	0.9218	0.0457*	0.0011**	0.5457	N/A	<0.0001****
AC	0.0164*	0.9888	0.0002***	0.0526	0.2076	0.0008***	<0.0001****	N/A
B.
	ada	bnb	DL	knn	rf	svc	Consensus	AC
ada	N/A	0.2912	0.4071	0.6165	0.4803	0.3956	0.4803	0.2382
bnb	0.2912	N/A	0.0355*	0.3842	0.4932	0.0287*	0.0483*	0.8944
DL	0.4071	0.0355*	N/A	0.1153	0.1106	>0.9999	0.8143	0.0587
knn	0.6165	0.3842	0.1153	N/A	0.9430	0.1106	0.2221	0.6753
rf	0.4803	0.4932	0.1106	0.9430	N/A	0.0890	0.1305	0.6456
svc	0.3956	0.0287*	>0.9999	0.1106	0.0890	N/A	0.9593	0.0459*
Consensus	0.4803	0.0483*	0.8143	0.2221	0.1305	0.9593	N/A	0.0533
AC	0.2382	0.8944	0.0587	0.6753	0.6456	0.0459*	0.0533	N/A
C.
	ada	bnb	DL	knn	rf	svc	Consensus	AC
ada	N/A	0.0025**	0.1448	0.6444	0.1151	0.0756	0.1524	0.0205*
bnb	0.0025**	N/A	<0.0001****	0.0217*	0.2818	<0.0001****	<0.0001****	0.6456
DL	0.1448	<0.0001****	N/A	0.0349*	0.0023**	0.4499	0.6159	<0.0001****
knn	0.6444	0.0217*	0.0349*	N/A	0.2008	0.0263*	0.0534	0.0820
rf	0.1151	0.2818	0.0023**	0.2008	N/A	0.0012**	0.0022**	0.5364
svc	0.0756	<0.0001****	0.4499	0.0263*	0.0012**	N/A	0.3187	<0.0001****
Consensus	0.1524	<0.0001****	0.6159	0.0534	0.0022**	0.3187	N/A	0.0001***
AC	0.0205*	0.6456	<0.0001****	0.0820	0.5364	<0.0001****	0.0001***	N/A