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. 2020 Nov 30;12:159. doi: 10.1186/s13195-020-00727-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Quantification of Lewy bodies and Lewy neurites in PD and DLB. IGG-1, I GG-2, IGG-3. No difference in % area LBs in the temporal cortex and SN of PD cases was observed between each of the antibodies and NOV (a, c). b However, significantly more LNs were detected with IGG-2 and IGG-1 antibodies compared to IGG-3 and NOV (P < 0.0001); in the TC, there was no difference between IGG-3 and NOV. In addition, IGG-2 stained more LNs than IGG-1 in the temporal cortex of PD cases (P < 0.0001). d In the SN of PD cases, the % area LNs was greater for IGG-1 (P = 0.002), IGG-2 (P < 0.0001) and IGG-3 (P < 0.0001) compared to NOV. in addition IGG-3 was significantly greater than IGG-1 (P = 0.028) (d). e % area LBs detected by IGG-3 (P = 0.006) and IGG-2 (P = 0.001) was significantly greater than NOV. In addition, IGG-2 stained more LBs than IGG-1 in TC of DLB cases (P = 0.014). f Significantly more LNs were detected with IGG-2 compared to IGG-1, IGG-3 and NOV (P < 0.0001). In addition, IGG-1 stained more LNs than NOV in TC of DLB cases (P < 0.0001), but there was no difference between IGG-3 and NOV. g IGG-2 (P = 0.001) and IGG-3 (P < 0.0001) showed greater % area LBs in SN of DLB cases compared to NOV. IGG-3 also detected a higher level of LBs compared to IGG-1 (P = 0.002). h All antibodies showed significantly higher detection of LNs in SN compared to NOV in which the greatest difference occurred with IGG-3 (P < 0.0001) and the smallest with IGG-1 (P = 0.017). % area LNs with IGG-3 was also significantly higher than both IGG-1 (P < 0.0001) and IGG-2 (P = 0.001). In addition, IGG-2 was greater than IGG-1 (P = 0.013). Error bars show mean ± 95% CI