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. 2020 Nov 30;12:159. doi: 10.1186/s13195-020-00727-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — α-Syn immunoreactivity in dementia with Lewy bodies. Representative images and corresponding quantification of α-Syn immunoreactivity obtained using IGG-1, IGG-2, IGG-3 and NOV. α-Syn-positive inclusions were detected with both NOV and all 3 antibodies in each brain region. IGG-1, IGG-2 and IGG-3 detected a significantly higher quantity of α-Syn inclusions than NOV in all brain regions (except IGG-1 in substantia nigra) (P < 0.05). IGG-2 and IGG-3 detected a significantly higher quantity than IGG-1 in all brain regions except the cortical GM and internal capsule (P < 0.05). α-Syn detected by IGG-3 was significantly higher than IGG-2 in the substantia nigra, putamen and temporal cortex (P > 0.0001). Error bars show mean ± 95% CI. Scale bar = 100 μm