. Author manuscript; available in PMC: 2020 Nov 30.

Published in final edited form as: AAPS J. 2016 Jul 8;18(5):1289–1299. doi: 10.1208/s12248-016-9951-9

Table 2.

Pharmacokinetic parameters of the four analytes in male SD rats after oral administration of 10 mg/kg and 20 mg/kg of kaempferol.

Compounds	doses	C_max (μmol/L)	T_max (min)	AUC_0-t (min•μmol/L)	AUC_0−∞ (min•μmol/L)	MRT_0-t (min)

Kaempferol	10 mg/kg	0.305 ± 0.106	26.7 ± 5.8	10.3 ± 3.8	11.4 ± 3.7	26.2 ± 1.8
	20 mg/kg	0.647 ± 0.244	18.0 ± 11.0	51.8 ± 17.2	57.9 ± 13.6	148 ± 68
K-3-G	10 mg/kg	24.6 ± 7.0	20.0 ± 8.9	(1.74 ± 0.47) ×10³	(1.76 ± 0.46) ×10³	88.8 ± 14.0
	20 mg/kg	30.9 ± 5.5	24.0 ± 5.5	(2.79 ± 0.33) ×10³	(2.81 ± 0.33) ×10³	114 ± 28
K-7-G	10 mg/kg	5.29 ± 2.97	17.5 ± 5.0	310 ± 95	314 ± 96	126 ± 37
	20 mg/kg	9.55 ± 3.37	16.0 ± 5.5	802 ± 231	811 ± 311	130 ± 43
K-7-S	10 mg/kg	0.332 ± 0.085	(1.12 ± 0.57) ×10³	454 ± 90	536 ± 164	(1.05 ± 0.12) ×10³
	20 mg/kg	0.703 ± 0.296	912 ± 768	(1.15 ± 0.22) ×10³	(1.65 ± 0.56) ×10³	(1.09 ± 0.11) ×10³

Data represent mean ± SD, n = 6. Abbreviations: C_max, maximum plasma concentration; T_max, time to reach maximum drug concentration; AUC_0-t, area under plasma concentration-time curve; AUC_0−∞, predicted area under plasma concentration-time curve; MRT_0-t, mean residence time.