Table 3.

Pharmacokinetic parameters of the three analytes in wild-type and knockout FVB mice after an oral administration of kaempferol (10 mg/kg).

Parameters	Compounds	FVB	Mrp1−/−	Mrp2−/−	Bcrp1−/−	Mdr1a−/−
Cmax	3-G	8.92 ± 1.69	1.75 ± 1.18**	32.3 ± 9.7**	18.0 ± 6.4**	4.62 ± 1.14**
(μmol/L)	7-G	2.91 ± 1.94	0.839 ± 0.853	14.3 ± 4.8**	14.9 ± 3.6**	1.12 ± 0.68
	7-S	0.301 ± 0.185	0.153 ± 0.062	0.616 ± 0.059*	1.09 ± 0.21**	0.141 ± 0.101
AUC0-t	3-G	365 ± 195	38.0 ± 29.1**	(1.28 ± 0.27) ×103**	848 ± 123**	143 ± 83*
(min•μmol/L)	7-G	114 ± 79	13.9 ± 12.0*	392 ± 78**	464 ± 234*	63.1 ± 15.3
	7-S	49.5 ± 38.6	6.72 ± 5.83*	102 ± 10*	156 ± 55**	36.7 ± 37.0
MRT	3-G	103 ± 29	33.4 ± 19.9**	90.5 ± 11.0	97.3 ± 21.7	113 ± 71
(min)	7-G	81.3 ± 34.2	25.8 ± 16.6**	90.9 ± 18.1	45.4 ± 22.3	244 ± 22**
	7-S	165 ± 59	57.3 ± 23.9**	197 ± 13	157 ± 8	237 ± 92

Data represent mean ± SD, n = 5~6.

^*p<0.05;

^**p<0.01.