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. 2020 Nov 30;11:513. doi: 10.1186/s13287-020-02012-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Experimental flowchart for inducing PF in rats’ left lung, administration of therapeutic agents nintedanib and pirfenidone, and transplantation of HUMSCs. The day when 5 mg BLM was injected into rats’ left bronchus was set as day 0. On day 21 following BLM injection, either daily administration of nintedanib/pirfenidone was initiated or one single transplantation of HUMSCs was conducted. After 4 weeks, the changes in the lung were observed, and various assessments were performed (a). The rats were divided into a total of five groups (b)