Figure 1.

Schematic overview: Differential gene expression in the contralateral and ipsilateral hippocampi at 24 h after status epilepticus induction. Both the ipsilateral and contralateral hippocampi were exposed to epileptic activity (upon a status epilepticus lasting several hours), but only the ipsilateral hippocampus gradually develops morphological alterations such as reactive gliosis and neuronal death (hippocampal sclerosis). In this study, gene expression was compared between epileptic mice (kainate injected over the right, ipsilateral, hippocampus) and sham mice (saline injected at the same location) for the contralateral hippocampus (CLH, blue arrow). This data was compared to previous data on gene expression from the ipsilateral hippocampus (ILH, red arrow). Differentially expressed genes associated with epileptic activity are represented by the blue boxes. Differentially expressed genes potentially associated with morphological alterations typical of mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) are represented by the red box.