Table 2.
Differentially expressed genes in glia in the contralateral hippocampus (CLH) at 24 h after kainate-induced status epilepticus.
| Gene symbol | logFC | FDR | Gene description |
|---|---|---|---|
| UPREGULATED GENES (N = 74) | |||
| Socs3 | 5.55 | 0.00 | Suppressor of cytokine signaling 3 |
| Fos | 5.82 | 0.00 | FBJ osteosarcoma oncogene |
| Serpina3n | 4.19 | 0.00 | Serine (or cysteine) peptidase inhibitor, clade A, member 3N |
| Cebpd | 2.82 | 0.01 | CCAAT/enhancer binding protein delta |
| Tnfrsf12a | 3.85 | 0.01 | Tumor necrosis factor receptor superfamily, member 12a |
| Gadd45b | 5.36 | 0.01 | Growth arrest and DNA-damage-inducible 45 beta |
| Emp1 | 4.30 | 0.01 | Epithelial membrane protein 1 |
| Ier5l | 2.81 | 0.01 | Immediate early response 5-like |
| S1pr3 | 3.68 | 0.01 | Sphingosine-1-phosphate receptor 3 |
| Egr1 | 4.17 | 0.01 | Early growth response 1 |
| Timp1 | 5.61 | 0.01 | Tissue inhibitor of metalloproteinase 1 |
| Egr2 | 3.11 | 0.01 | Early growth response 2 |
| Tubb6 | 3.24 | 0.01 | Tubulin, beta 6 class V |
| Cd44 | 3.89 | 0.01 | CD44 antigen |
| Gadd45g | 3.13 | 0.02 | Growth arrest and DNA-damage-inducible 45 gamma |
| Ccl2 | 3.28 | 0.02 | Chemokine (C-C motif) ligand 2 |
| Junb | 3.68 | 0.02 | Jun B proto-oncogene |
| Ptx3 | 5.09 | 0.02 | Pentraxin related gene |
| Fosb | 3.92 | 0.02 | FBJ osteosarcoma oncogene B |
| Tm4sf1 | 4.35 | 0.02 | Transmembrane 4 superfamily member 1 |
| Sphk1 | 3.78 | 0.02 | Sphingosine kinase 1 |
| Gm3448 | 2.79 | 0.02 | Predicted gene 3448 |
| Ccl12 | 4.33 | 0.02 | Chemokine (C-C motif) ligand 12 |
| Vgf | 3.00 | 0.02 | VGF nerve growth factor inducible |
| Fstl4 | 2.60 | 0.03 | Follistatin-like 4 |
| Myc | 2.84 | 0.03 | Myelocytomatosis oncogene |
| Itga5 | 3.38 | 0.03 | Integrin alpha 5 (fibronectin receptor alpha) |
| Cebpb | 2.35 | 0.03 | CCAAT/enhancer binding protein (C/EBP), beta |
| Arid5a | 2.05 | 0.03 | AT rich interactive domain 5A (MRF1-like) |
| Ier3 | 2.61 | 0.04 | Immediate early response 3 |
| Thbd | 2.01 | 0.04 | Thrombomodulin |
| Adamts1 | 2.86 | 0.05 | A disintegrin-like and metallopeptidase with thrombospondin type 1 motif, 1 |
| Ecm1 | 2.09 | 0.05 | Extracellular matrix protein 1 |
| Sbno2 | 2.62 | 0.05 | Strawberry notch 2 |
| Slc39a14 | 2.19 | 0.05 | Solute carrier family 39 member 14 |
| Hmga1b | 2.22 | 0.05 | High mobility group AT-hook 1B |
| Il1r1 | 1.90 | 0.06 | Interleukin 1 receptor, type I |
| Klk9 | 3.35 | 0.06 | Kallikrein related-peptidase 9 |
| Dusp5 | 2.25 | 0.07 | Dual specificity phosphatase 5 |
| Ucn2 | 5.70 | 0.08 | Urocortin 2 |
| Gpr151 | 3.15 | 0.08 | G protein-coupled receptor 151 |
| Ier2 | 2.71 | 0.08 | Immediate early response 2 |
| Mafk | 2.96 | 0.08 | V-maf musculoaponeurotic fibrosarcoma oncogene family, protein K |
| Csrnp1 | 2.60 | 0.08 | Cysteine–serine-rich nuclear protein 1 |
| Itga7 | 1.74 | 0.09 | Integrin alpha 7 |
| Fosl2 | 2.05 | 0.10 | Fos-like antigen 2 |
| Bcl3 | 5.25 | 0.10 | B cell leukemia/lymphoma 3 |
| Atf3 | 4.24 | 0.12 | Activating transcription factor 3 |
| Fosl1 | 2.36 | 0.13 | Fos-like antigen 1 |
| Hmga1 | 2.49 | 0.13 | High mobility group AT-hook 1 |
| Loxl1 | 2.05 | 0.13 | Lysyl oxidase-like 1 |
| Mchr1 | 2.23 | 0.13 | Melanin-concentrating hormone receptor 1 |
| Kdm6b | 1.71 | 0.13 | KDM1 lysine (K)-specific demethylase 6B |
| Odc1 | 1.90 | 0.13 | Ornithine decarboxylase, structural 1 |
| Cd244a | 2.96 | 0.13 | CD244 molecule A |
| Msr1 | 3.59 | 0.15 | Macrophage scavenger receptor 1 |
| Sv2c | 2.70 | 0.15 | Synaptic vesicle glycoprotein 2c |
| Tma16 | 1.82 | 0.16 | Translation machinery associated 16 |
| C2cd4b | 2.69 | 0.16 | C2 calcium-dependent domain containing 4B |
| Egr4 | 2.41 | 0.16 | Early growth response 4 |
| Hspb1 | 3.46 | 0.17 | Heat shock protein 1 |
| Tnc | 1.67 | 0.17 | Tenascin C |
| Srxn1 | 1.92 | 0.17 | Sulfiredoxin 1 homolog |
| Ahnak2 | 2.75 | 0.17 | AHNAK nucleoprotein 2 |
| Wwtr1 | 1.64 | 0.17 | WW domain containing transcription regulator 1 |
| Gpr3 | 2.00 | 0.18 | G-protein coupled receptor 3 |
| Zfp36 | 2.57 | 0.18 | Zinc finger protein 36 |
| Trib1 | 1.95 | 0.18 | Tribbles pseudokinase 1 |
| Il11 | 2.88 | 0.21 | Interleukin 11 |
| Rhoj | 2.62 | 0.21 | Ras homolog family member J |
| Hcar2 | 3.17 | 0.21 | Hydroxycarboxylic acid receptor 2 |
| Cdh22 | 2.02 | 0.24 | Cadherin 22 |
| Pvr | 1.49 | 0.25 | Poliovirus receptor |
| Slc7a1 | 1.23 | 0.25 | Solute carrier family 7 member 1 |
| DOWNREGULATED GENES (N = 22) | |||
| Nat8f4 | −2.30 | 0.01 | N-acetyltransferase 8 (GCN5-related) family member 4 |
| Hapln1 | −2.80 | 0.03 | Hyaluronan and proteoglycan link protein 1 |
| Aifm3 | −2.17 | 0.03 | Apoptosis-inducing factor, mitochondrion-associated 3 |
| Btbd17 | −2.31 | 0.03 | BTB (POZ) domain containing 17 |
| Nwd1 | −2.35 | 0.04 | NACHT and WD repeat domain containing 1 |
| Gdpd2 | −2.40 | 0.06 | Glycerophosphodiester phosphodiesterase domain containing 2 |
| Slc2a5 | −2.28 | 0.08 | Solute carrier family 2 member 5 |
| P2ry12 | −2.63 | 0.09 | Purinergic receptor P2Y, G-protein coupled 12 |
| Gpr165 | −2.10 | 0.10 | G protein-coupled receptor 165 |
| Tet1 | −1.41 | 0.13 | Tet methylcytosine dioxygenase 1 |
| 2900052N01Rik | −2.38 | 0.15 | 2900052N01Rik |
| Susd5 | −2.04 | 0.15 | Sushi domain containing 5 |
| Maf | −1.49 | 0.17 | Avian musculoaponeurotic fibrosarcoma oncogene homolog |
| Fn3k | −1.87 | 0.17 | Fructosamine 3 kinase |
| Tmem255b | −2.02 | 0.17 | Transmembrane protein 255B |
| Traf4 | −1.75 | 0.17 | TNF receptor associated factor 4 |
| Fam228a | −1.73 | 0.17 | Family with sequence similarity 228, member A |
| Paqr7 | −1.94 | 0.20 | Progestin and adipoQ receptor family member VII |
| Gpr34 | −2.49 | 0.21 | G protein-coupled receptor 34 |
| Sowaha | −1.46 | 0.21 | Sosondowah ankyrin repeat domain family member A |
| Phkg1 | −1.77 | 0.25 | Phosphorylase kinase gamma 1 |
| Folh1 | −2.08 | 0.25 | Folate hydrolase 1 |
Differentially expressed genes in glia in the contralateral hippocampus (FDR < 0.25).
logFC, log fold change; FDR, false discovery rate.