Table 3.
Selection of relevant Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) terms of the differentially expressed genes in neurons in the contralateral hippocampus (CLH) at 24 h after kainate-induced status epilepticus.
|
Upregulated in neurons (115 genes) |
Downregulated in neurons (16 genes) |
|
|---|---|---|
| GO | Cell death | Positive regulation of calcium ion transport |
| Regulation of cell proliferation | Axon guidance | |
| Cell communication | Vesicle organization | |
| MAPK cascade | Regulation of DNA-binding transcription factor activity | |
| Cell surface receptor signaling pathway | Axonogenesis | |
| Regulation of transcription, DNA-templated | Growth factor activity | |
| Vasculature development | Programmed cell death | |
| Inflammatory response | Blood vessel morphogenesis | |
| KEGG | Cytokine-cytokine receptor interaction | Axon guidance |
| cAMP signaling pathway | NF-kappa B signaling pathway | |
| ECM–receptor interaction | Leukocyte transendothelial migration | |
| IL-17 signaling pathway | – | |
| TGF-beta signaling pathway | – | |
| TNF signaling pathway | – | |
| MAPK signaling pathway | – | |
| p53 signaling pathway | – | |
| VEGF signaling pathway | – | |
| JAK-STAT signaling pathway | – |
Relevant GO and KEGG terms among the significantly differentially expressed genes (FDR < 0.25).