Table 5.
Differentially expressed genes in neurons exclusively in the ILH (and not the CLH) at 24 h after kainate-induced status epilepticus.
| Gene symbol | logFC.ILH | FDR.ILH | Gene description |
|---|---|---|---|
| UPREGULATED GENES (N = 55; ILH: 132) | |||
| Hspa1a | 5.46 | 0.01 | Heat shock protein 1A |
| Mapk4 | 2.28 | 0.01 | Mitogen-activated protein kinase 4 |
| Hspa1b | 4.82 | 0.02 | Heat shock protein 1B |
| Pcdh11x | 2.26 | 0.03 | Protocadherin 11 X-linked |
| Pde6b | 2.91 | 0.03 | Phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide |
| Wisp1 | 2.09 | 0.03 | WNT1-inducible-signaling pathway protein 1 |
| 9330188P03Rik | 3.35 | 0.03 | RIKEN cDNA 9330188P03 gene |
| Hspb1 | 4.00 | 0.03 | Heat shock protein 1 |
| Lbh | 3.01 | 0.03 | Limb-bud and heart |
| Rrad | 4.89 | 0.04 | Ras-related associated with diabetes |
| 4931440P22Rik | 1.70 | 0.04 | RIKEN cDNA 4931440P22 gene |
| Cyr61 | 2.90 | 0.04 | Cysteine-rich angiogenic inducer 61 |
| Zbtb46 | 1.58 | 0.05 | Zinc finger and BTB domain containing 46 |
| Bach1 | 1.72 | 0.05 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 |
| Samd4 | 1.90 | 0.05 | Sterile alpha motif domain containing 4 |
| Npas4 | 3.24 | 0.06 | Neuronal PAS domain protein 4 |
| Adam19 | 1.62 | 0.08 | A disintegrin and metallopeptidase domain 19 (meltrin beta) |
| Pim1 | 2.43 | 0.08 | Proviral integration site 1 |
| Mapkapk3 | 1.97 | 0.09 | Mitogen-activated protein kinase-activated protein kinase 3 |
| Cdh4 | 1.45 | 0.09 | Cadherin 4 |
| Kdm6b | 1.57 | 0.09 | KDM1 lysine (K)-specific demethylase 6B |
| Spp1 | 3.14 | 0.09 | Secreted phosphoprotein 1 |
| Sorcs3 | 2.28 | 0.09 | Sortilin-related VPS10 domain containing receptor 3 |
| Uck2 | 1.35 | 0.10 | Uridine–cytidine kinase 2 |
| Plce1 | 1.40 | 0.10 | Phospholipase C, epsilon 1 |
| Tgfb1i1 | 1.66 | 0.10 | Transforming growth factor beta-1-induced transcript 1 |
| Frrs1 | 1.87 | 0.12 | Ferric-chelate reductase 1 |
| Blnk | 2.81 | 0.12 | B cell linker |
| Rgs20 | 1.74 | 0.12 | Regulator of G-protein signaling 20 |
| Itprip | 1.88 | 0.13 | Inositol 1,4,5-triphosphate receptor interacting protein |
| Smad7 | 1.83 | 0.13 | SMAD family member 7 |
| Svil | 1.52 | 0.13 | Supervillin |
| Mir132 | 3.39 | 0.15 | MicroRNA 132 |
| Zdhhc22 | 1.85 | 0.17 | Zinc finger, DHHC-type containing 22 |
| Amotl1 | 1.71 | 0.18 | Angiomotin-like 1 |
| Serpina3i | 2.75 | 0.18 | Serine (or cysteine) peptidase inhibitor, clade A, member 3I |
| Ifit1 | 2.33 | 0.18 | Interferon-induced protein with tetratricopeptide repeats 1 |
| Kcnip3 | 1.67 | 0.18 | Kv channel interacting protein 3, calsenilin |
| Odc1 | 1.57 | 0.18 | Ornithine decarboxylase, structural 1 |
| Igsf9b | 2.27 | 0.18 | Immunoglobulin superfamily, member 9B |
| Spred1 | 1.62 | 0.18 | Sprouty protein with EVH-1 domain 1, related sequence |
| Samd11 | 2.19 | 0.19 | Sterile alpha motif domain containing 11 |
| Scd4 | 2.01 | 0.19 | Stearoyl-coenzyme A desaturase 4 |
| Dusp4 | 1.88 | 0.19 | Dual specificity phosphatase 4 |
| Tspan9 | 1.68 | 0.19 | Tetraspanin 9 |
| Eva1b | 2.00 | 0.19 | Eva-1 homolog B (C. elegans) |
| Btc | 2.40 | 0.19 | Betacellulin, epidermal growth factor family member |
| St8sia2 | 2.11 | 0.20 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 |
| Tm4sf1 | 2.49 | 0.20 | Transmembrane 4 superfamily member 1 |
| Cdh22 | 1.77 | 0.20 | Cadherin 22 |
| Itga5 | 2.11 | 0.21 | Integrin alpha 5 (fibronectin receptor alpha) |
| Mapk6 | 1.51 | 0.22 | Mitogen-activated protein kinase 6 |
| Egr4 | 1.91 | 0.23 | Early growth response 4 |
| Itpkc | 1.84 | 0.23 | Inositol 1,4,5-trisphosphate 3-kinase C |
| Drd1 | 1.82 | 0.25 | Dopamine receptor D1 |
| DOWNREGULATED GENES (N = 7; ILH: 15) | |||
| Echdc2 | −1.77 | 0.08 | Enoyl coenzyme A hydratase domain containing 2 |
| Cyp7b1 | −2.28 | 0.10 | Cytochrome P450, family 7, subfamily b, polypeptide 1 |
| Gstm6 | −1.57 | 0.16 | Glutathione S-transferase, mu 6 |
| Crlf1 | −1.97 | 0.19 | Cytokine receptor-like factor 1 |
| Macrod1 | −1.52 | 0.20 | MACRO domain containing 1 |
| Gm35339 | −1.43 | 0.20 | Predicted gene, 35339 |
| 6330420H09Rik | −2.15 | 0.22 | RIKEN cDNA 6330420H09 gene |
Differentially expressed genes in neurons exclusively in the ipsilateral hippocampus (FDR < 0.25).
logFC, log fold change; FDR, false discovery rate; ILH, ipsilateral hippocampus; CLH, contralateral hippocampus.