Table 1.

Summary of the Various Data Used in the SiMLR Statistical Framework

Demographics • Age • Education • Number of breaches (last year) • Number of breaches (career)	Neuroimaging • Structural ○ Cortical thickness (by T1-/T2-w MRI) ○ FA (by DWI) ○ Radial diffusivity (by DWI) • Functional ○ fALFF (by rs-fMRI) ○ default mode network (by rs-fMRI) ○ β (perfusion, by gadolinium-enhanced contrast)
Psychometric batteries • Wechsler Test of Adult Reading • Wechsler Memory Scale • Wechsler Abbreviated Scale of Intelligence • Rey-Osterrieth Complex Figure Test • Immediate Post Concussion Assessment and Cognitive Testing • Automated Neuropsychological Assessment Metrics (ANAM4) • Booklet Category Test • Delis Kaplan Executive Functioning- Sorting Test	Fluid biomarkers (exosome) • Inflammation ○ Interleukin-6 ○ Interleukin-10 ○ Tumor necrosis factor-α • Neural injury ○ Neurofilament light ○ Tau ○ Aβ42

Although not all data collected were used, a selection encompassing the various aspects of effects observed in traumatic brain injury were selected.

SiMLR, similarity-driven multi-view linear reconstruction; T1-w, T₁-weighted; T2-w, T₂-weighted; MRI, magnetic resonance imaging; FA, fractional anisotropy; DWI, diffusion-weighted imaging; fALFF, fractional amplitude of low-frequency fluctuation; rs-fMRI, resting-state functional magnetic resonance imaging; Aβ42, beta-amyloid 42.