Table 1.

Components of the ‘DOT to DAT’ trial intervention and corresponding barriers addressed

Component		Barrier addressed
1	Daily dosing reminders via automated SMS	Addresses high cost of clinic visits for patients and assists with memory and planning processes known to be importance to adherence.
2	Daily dosing confirmation via toll-free phone calls	Addresses high cost of clinic visits for patients, lack of real-time information for providers on patient adherence to medications.
3	Weekly check-in via interactive voice response phone calls	Addresses lack of social support and feeling of isolation during TB treatment; shown to be effective in other contexts at increasing connection with community health workers and reducing social isolation.
4	Differential management protocol	Addresses limited time and resources among TB treatment unit staff and the need to focus on non-adherent patients.

TB, tuberculosis.