Table 7.

Cytoscape Modules of Target Proteins with Linkers using ReactomeFI App

Rank	Modules of target proteins with linkers	Top pathway for each module
1	ACTB, CDC42, ELK4, FASN, FYN, IGF1R, IQGAP1, PTPRJ, SETD7, ZNF703	Adherens junction (KEGG hsa 04520)
	(Linkers: CCT8, CSNK2A2, CTNNB1, MAPK3, STAT3)
2	BAG6, DYRK1A, EWSR1, H3F3B, KMT2D, SCD, SIN3A	Transcriptional misregulation in cancer (KEGG hsa05202)
	(Linkers: EP300, HIST1H4A, RXRA)
3	DDX5, HNRNPC, NCL, PCBP2, PRPF8, SCARB2, TCF3	Processing of capped intron-containing pre-mRNA (Reactome R-HSA-75067)
	(Linker: HSPA8)
4	ASH1L, DCP2, DYNC1H1, SPOPL, TGFBR1	Beta5 beta6 beta7 and beta8 integrin cell surface interactions (NCI PID)
	(Linkers: SUFU, UBC)
5	CCND2, CCNE2, MCM7, RB1	Cell cycle (KEGG hsa04110)