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. 2020 Nov 30;90:107233. doi: 10.1016/j.intimp.2020.107233

Fig 1.

Fig 1

The neutrophil role in the lung tissue during infection by SARS-CoV-2. (1) The neutrophil-to-lymphocyte ratio (NLR) is elevated in the bloodstream. (2) The migrated neutrophils contribute to storm cytokines formation and release other mediators (e.g., elastase neutrophilic). (3) SARS-CoV-2 infection promotes neutrophil extracellular traps release, which can contribute to lung damage and (4) immunothrombosis. These many steps may be potential therapeutic targets. Several other cells and mediators are involved in COVID-19 immunopathology, but they are suppressed in this figure to highlight the neutrophil role. The figure was created with BioRender.com [119].