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. Author manuscript; available in PMC: 2020 Nov 30.

Published in final edited form as: J Med Chem. 2020 Feb 17;63(4):1724–1749. doi: 10.1021/acs.jmedchem.9b02149

Table 3.

Neutralization Activity of gp120 Entry Antagonists against an HIV-1 Panel of Paired Infant (B) and Maternal (M) Env Molecular Clones

			IC₅₀^a (μM)
subtype	NIH No.	ENV	Ref2	33	8
A	11518-B	BG505.W6M.ENV.C2	0.92 ± 0.16	1.38 ± 0.2	0.57 ± 0.06
A	11528-M	MG505.W0M.ENV.A2	0.93 ± 0.07	1.6 ± 0.08	0.47 ± 0.08.
A	11519-B	B1206.W6P.ENVA1A	0.75 ± 0.06	1.8 ± 0.07	0.53 ± 0.05
A	11531-M	MI206.W0M.ENV.D1	0.7 ± 0.02	1 ± 0.02	0.28 ± 0.01
A	11521-B	BJ613.W6M.ENV.E1	0.8 ± 0.07	0.94 ± 0.14	0.26 ± 0.01
A	11535-M	MJ613.W0M.ENV.A2	0.5 ± 0.05	0.63 ± 0.07	0.31 ± 0.07
D/A	11524-B	BL035.W6M.ENV.C1	0.52 ± 0.16	0.54 ± 0.04	0.42 ± 0.01
D/A	11538-M	ML035.W0M.ENV.G2	0.59 ± 0.08	0.86 ± 0.05	0.23 ± 0.01
A	11525-B	BL274.W6M.ENV.A3	0.63 ± 0.12	0.84 ± 0.09	0.37 ± 0.05
A	11540-M	ML274.W0M.ENV.B1	0.66 ± 0.1	0.88 ± 0.06	0.25 ± 0.03
mean ± SEM (μM): overall (n = 10)			0.7 ± 0.05	1.05 ± 0.13	0.37 ± 0.04
infant (B) (n = 5)			0.72 ± 0.07	1.1 ± 0.22	0.43 ± 0.07
mother (M) (n = 5)			0.68 ± 0.07	0.99 ± 0.16	0.31 ± 0.04

^a

The reported IC₅₀ values represent the means ± standard deviations (n = 3).