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. Author manuscript; available in PMC: 2020 Nov 30.
Published in final edited form as: J Med Chem. 2020 Feb 17;63(4):1724–1749. doi: 10.1021/acs.jmedchem.9b02149

Table 5.

Inhibitory Activity against Cell-to-Cell HIV Transmission by the gp120 Entry Antagonists

IC50a (μM)
compound TZMb-l/H9-HIV-1IIIB TZMb-l/Molt-HIV-1ADA
Ref2 0.46 ± 0.2 0.89 ± 0.14
33 0.45 ± 0.1 1.2 ± 0.4
8 0.47 ± 0.1 0.92 ± 0.13
BMS-626529 0.02 ± 0.005 ~0.2
a

The reported IC50 values represent the means ± standard deviation (SD), n = 3.