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. 2020 Nov 10;117(47):29904–29913. doi: 10.1073/pnas.2016589117

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Fig. 1. — An HFD remodels the circadian metabolome in the SCN and mPFC. (A) Total number of metabolites and number and percentage of oscillatory metabolites in the SCN and mPFC (JTK_CYCLE, P < 0.05). (B) Venn diagram showing the number and percentage of rhythmic metabolites in the SCN in NC-only, both diets, and HFD-only groups (JTK_CYCLE, P < 0.05). This Venn diagram is also shown in fig. 2 of ref. 30. (C) Venn diagram showing the number and percentage of rhythmic metabolites in the mPFC in the NC-only, both diets, and HFD-only groups (JTK_CYCLE, P < 0.05). This Venn diagram is also shown in fig. 2 of ref. 30. (B and C) Venn diagrams reprinted with permission from ref. 30. (D) Heat maps representing the circadian metabolites in the SCN in the NC-only, both diets, and HFD-only groups (n = 5 per time point per group; JTK_CYCLE, P < 0.05). (E) Heat maps representing the circadian metabolites in the mPFC in the NC-only, both conditions, and HFD-only groups (n = 5 per time point per group; JTK_CYCLE, P < 0.05). (F) Venn diagram for the NC-only group representing the circadian metabolites exclusively in the SCN (SCN NC only), in both the SCN and the mPFC, and exclusively in the mPFC (mPFC NC only). (G) Venn diagram for the both diets group showing the circadian metabolites exclusively in the SCN (SCN both), in both the SCN and the mPFC, and exclusively in the mPFC (mPFC both). (H) Venn diagram for the HFD-only group representing the circadian metabolites exclusively in the SCN (SCN HFD only), in both the SCN and mPFC, and exclusively in the mPFC (mPFC HFD only).