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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Allergy. 2020 Apr 24;75(8):1966–1978. doi: 10.1111/all.14254

Figure 2. Butyrate and propionate, but not acetate, inhibit IgE and non-IgE mediated mast cell activation.

Figure 2.

A, Percentage of mast cell degranulation (as measured by beta-hexosaminidase release) after IgE-mediated activation using either DNP-HSA or anti-IgE stimulation in mouse and human mast cells treated with increasing concentrations of acetate (left), propionate (middle) and butyrate (right). B, Percentage of degranulation after IgE- and non-IgE (C48/80 or Substance P) mediated mast cell activation in untreated or treated (5 mM butyrate, 24 h) human mast cells. C, Effects of butyrate and propionate on IL-6 cytokine production in mouse mast cells after IgE-mediated activation. Results are pooled from 3 independent experiments performed with mouse or human mast cells from 3 different donors (n=3/group). Data represent mean ± SEM, statistical significance was tested using a one-way ANOVA test: #, significantly increased compared to non-stimulated; *, Significantly decreased compared to control (P < 0.05). * P < 0.05; ** P < 0.01; ***, ### P < 0.001. NS = not significant, DNP-HSA = Dinitrophenyl - Human Serum Albumins, Sub. P. = Substance P.