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. Author manuscript; available in PMC: 2021 Aug 12.
Published in final edited form as: J Med Chem. 2020 Oct 23;63(21):12642–12665. doi: 10.1021/acs.jmedchem.0c00943

Scheme 4. Synthesis of Pyrazol-1-yl-propanamides 29a–29fa.

Scheme 4.

aReagents and conditions: (a) 1. SOCl2 in THF, −10 to 0 °C. 2. Et3N in THF, −10 to 0 °C and then heat to 50 °C, 2–3 h, and (b) NaH in THF, 0 °C to rt.