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. Author manuscript; available in PMC: 2021 Aug 12.
Published in final edited form as: J Med Chem. 2020 Oct 23;63(21):12642–12665. doi: 10.1021/acs.jmedchem.0c00943

Figure 9.

Figure 9.

SARDs and pan-antagonists inhibit growth of Enz-R PC. Enz-R MDVR cells (10 × 106 cells/rat) were implanted subcutaneously in male SRG (Sprague Dawley-Rag2: IL2rg KO) rats. When the tumors reached 1000–3000 mm3, the animals were randomized and treated (intact). Once the tumors attain 2000–3000 mm3, the animals were treated orally with vehicle (DMSO/PEG-300 15:85) or 10 mg/kg/day of 26a. Tumor volume (T.V.) was measured twice weekly and represented as a percent change (upper panel) or weight at sacrifice (lower panel).