Table 7.
In Vitro Metabolic Stability for Selective Compounds in RLM and HLM
| RLMa | HLMb | |||
|---|---|---|---|---|
| compound ID | T1/2 (min) | CLint (mL/min/mg) | T1/2 (min) | CLint (mL/min/mg) |
| 16c (4-Cl) | >120 | 0 | 102 | 6.78 |
| 16g (4-CF3) | >120 | 0 | >120 | 0 |
| 21a (4-F) | >120 | 0 | >120 | 0 |
| 26a (3-F, 4-Br) | >120 | 0 | >120 | 0 |
a
Compounds were incubated together with RLM with cofactors for phases I and II provided, as described in the Experimental Section.
b
Compounds were incubated together with HLM with cofactors for phases I and II provided, as described in the Experimental Section.