FIG. 2.

CovMulNet19 COVID-19 genotype–phenotype–drug interaction network. Result of the data integration and processing procedures illustrated schematically in Figure 1. (A) Nodes and schematic map of interdependencies among different layers encoding diseases, symptoms, drugs, GO terms, human proteins, and viral proteins. (B) Map of the reconstructed structural interactions (e.g., protein–protein) and functional interdependencies (e.g., protein–disease, protein–GO term, or disease–symptom). Overall, the network consists of 1999 protein–protein, 19,755 protein–disease, 10,152 protein–symptom, 13,018 drug–target, 9210 protein–GO, and 3056 disease–symptom relationships.