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. 2020 Nov 17;3(1):130–141. doi: 10.1089/nsm.2020.0011

FIG. 3.

FIG. 3.

Top 25 over-represented GO terms, drugs, diseases, and symptoms in CovMulNet19. The 25 most over-represented GO terms (A), drugs (B), diseases (C), and symptoms (D) are ranked based on their z-scores calculated on structural strength using the bootstrap sampling procedure. The top X-axis shows z-score values and bottom X-axis shows structural degrees (nodes degrees to protein nodes). Red and blue bars depict z-scores calculated on the structural degrees and on their structural strength (i.e., degrees to proteins relatively to the total degrees to proteins from all nodes), respectively. Purple bars represent the nodes' structural degrees observed in CovMulNet19's network. Terms preceded with a (*) or (**) were significantly over-represented in CovMulNet19 compared with observed appearance in the mock random networks (p-value <0.1 and 0.05, respectively). The complete list of nodes with their associated z-scores and p-values can be accessed in the bootstrap results tables in supplementary data (Supplementary Tables S1 and S2).