Fig. 2.

A schematic of the domain structure of SOX family transcription factors. Sox groups A-H are grouped based on their DNA-binding high mobility group (HMG) domain. The domain architecture of SOX proteins varies between each group and harbour additional motifs, such as Transcriptional Activation/Repressor domains (SOX domains reviewed in: Ref. [3]). SOX30 is uniquely expressed in humans and is related to SOXD family proteins through the remanence of a coiled-coiled domain. Proteins are drawn to scale.