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. Author manuscript; available in PMC: 2020 Nov 30.
Published in final edited form as: JAMA Dermatol. 2015 Jan;151(1):23–32. doi: 10.1001/jamadermatol.2014.1550

Table 1.

Characteristics of Patients With cGvHD and Vitiligo and/or AA

Vitiligo and/or AA cGvHD Involvement
Patient No./Sexa,b,c Disease Transplant Conditioning Graft Type Time to Occurrence, mo Distribution Vitiligo Type Skin Other Organs
1/M CML Bu/Cyc BM 24 Perioral, torso, R buttock, pretibial legs Torso Epid Eyes, lungs, liver
2/M APL … PB … Periorbital/oral, head/neck, back, fingers Classicd Bothe Eyes, oral, GI
3/F FNHL Flu/Cyc PB … Periorbital, perioral, L cheek, back Classicd Epid Eyes
4/M RMSA Flu/Cyc/Mel PB … B/L cheeks, head/neck, upper chest, UE, LE Generalized Bothe Eyes, oral, lungs, joint
5/M CML Bu/Cyc/VP-16 BM … Perioral Classicd Bothe Eyes, oral, GI, joint
6/M CML Bu/Flu/ATG BM 36 Perioral, cheeks, acral, UE, genitalia Classicd Bothe Eyes, oral, GI, liver, genital
7/F CML Bu/Flu/ATG PB … Trichrome face, chest, upper back, B/L thighs Classicd None Eyes, oral, lungs, GI, joint
8/Ma,b WAS … Cord … Diffuse trichrome vitiligo Generalized Bothe Lungs, joint
9/F AML Flu/TBI PB 36 Face, chest, lower back, B/LUE, LE Generalized Scl Eyes, oral, lungs, GI, joint
10/Fb,c AML Flu/Cyc/TBI Cord … Vitiligo: face, postauricular, neck, trunk, UE, LE AA: scalp vertex Generalized Epid Lungs, vulvovaginal
11/M CLL Flu/Cyc PB … Face, scalp, neck, anterior trunk Generalized Bothe Eyes, oral, liver, joint
12/M B-cell ALL Cyc/TBI PB … Periorbital, perioral, scalp, chin Classicd Epid Oral, lungs
13/F CTCL Flu/Mel PB … Neck, trunk, proximal UE Torso Bothe Eyes, lungs, GI, liver, genital
14/M CML Bu/Cyc PB 84 Trichrome face, trunk, B/LUE Generalized Bothe Eyes, oral, lungs, liver
15/Mc ALL Cyc/VP-16/TBI BM 24 Scalp NA None Lungs, GI

Abbreviations: AA, alopecia areata; ALL, acute lymphoblastic leukemia; AML, acute myelogenous leukemia; APL, acute promyelocytic leukemia; ATG, antithymocyte globulin; B/L, bilateral; BM, bone marrow; Bu, busulfan; cGvHD, chronic graft-vs-host disease; CLL, chronic lymphocytic leukemia; CML, chronic myelogenous leukemia; CTCL, cutaneous T-cell lymphoma; Cyc, cyclophosphamide; epid, epidermal; Flu, fludarabine; FNHL, follicular non-Hodgkin lymphoma; GI, gastrointestinal tract; L, left; LE, lower extremities; Mel; melphalan; NA, not applicable; PB, peripheral blood; R, right; RMSA, rhabdomyosarcoma; Scl, sclerotic; TBI, total body irradiation; UE, upper extremities; VP-16, etoposide; WAS, Wiskott-Aldrich syndrome; …, not known.

a

All patients whose donor sex was known received transplants from female donors; donor sex for patient 8 was not reported.

b

Thirteen of the 15 patients had an HLA-identical donor; a mismatch occurred only with patients 8 and 10.

c

Thirteen of the 15 patients had only vitiligo; patient 10 had both vitiligo and AA; patient 15 had only AA.

d

Classic indicates predominantly perioral, periorbital, and acrofacial involvement; torso, predominantly truncal involvement; generalized, diffuse involvement.

e

Both indicates both sclerotic and epidermal cGvHD involvement.