Fig. 3.

The adaptive density-aware kernel demonstrates an advantage in multi-omic analysis. On the right-hand side of the panel are the results for the Zelnik-Manor kernel, while the density-aware kernel results are shown on the left-hand side. (a) Spectrum clustering assignments from the brain cancer dataset (Ceccarelli et al., 2016), UMAP was run on the integrated similarity matrices for mRNA, miRNA and protein data to generate the plots. (b) Survival curves with P values from a Cox proportional hazards regression model using a log-rank test to assess significance between clusters