Table 4.

Univariable and multivariable Cox analysis of overall survival (OS)

Variable		Univariable		Multivariable
		HR (95% CI)	p value	HR (95% CI)	p value
Age at diagnosis	≥65 vs. <65 years	1.35 (0.99–1.85)	0.058	1.30 (0.93–1.84)	0.127
Sex	Female vs. male	0.82 (0.60–1.13)	0.221
Race/ethnicity	White (ref)
	Black	1.24 (0.73–2.10)	0.430	1.31 (0.75–2.28)	0.341
	Asian	0.57 (0.33–1.00)	0.052	0.52 (0.30–0.93)	0.028
	Hispanic	0.89 (0.61–1.29)	0.537	0.86 (0.58–1.27)	0.444
Location	GEJ vs. other	1.20 (0.85–1.69)	0.307
Histology grade	Poorly vs. well/moderately differentiated	1.08 (0.73–1.61)	0.691
Signet-ring cell	Yes vs. no	1.10 (0.81–1.49)	0.548
Linitis	Yes or suspicious	2.27 (1.47–3.51)	<0.001	1.66 (1.03–2.69)	0.037
ypStage	T0N0	1.24 (0.71–2.18)	0.452	1.29 (0.73–2.28)	0.377
	T0N1	4.08 (1.57–10.6)	0.004	4.34 (1.63–11.6)	0.003
	1 (ref)
	2	1.71 (1.09–2.67)	0.019	1.78 (1.11–2.83)	0.016
	3	3.36 (2.10–5.38)	<0.001	3.42 (2.08–5.60)	<0.001
	4	13.83 (7.30–26.2)	<0.001	13.11 (6.60–26.0)	<0.001
Concomitant organ resection	Yes vs. no	1.63 (1.13–2.35)	0.009	1.45 (0.99–2.11)	0.057
R1 resection	Yes vs. no	3.05 (1.90–4.89)	<0.001	1.91 (1.13–3.23)	0.016
Preoperative XRT	Yes vs. no	0.95 (0.66–1.37)	0.801
Adjuvant therapy	Yes vs. no	0.90 (0.58–1.40)	0.648
Number of LNs examined <16	Yes vs. no	1.25 (0.91–1.72)	0.169	1.38 (0.98–1.95)	0.061

p values <0.05 are in bold font