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. Author manuscript; available in PMC: 2020 Nov 30.
Published in final edited form as: Cell Rep. 2020 Nov 17;33(7):108402. doi: 10.1016/j.celrep.2020.108402

Table 1.

Genes Expressed in Abundance in Salivary Glands

Top Transcribed Genesa Specifically Expressed in Salivary
STATH, HTN3, HTN1, AMY1, SMR3B, PRH2, ENSG00000254144, CST4, RPPH1, CST1, PRB1, PRB3, PRB4, C6orf58, MUC19, ENSG00000225840, CD24P4, RIMBP3C, LINC00273
Top 20 Transcribed Genes in the SLb
RN7SL1, LYZ, ZG16B, MUC7, MTRNR2L8, PIGR, MUC5B, ENSG00000254144, CRISP3, STATH, C6orf58, RPPH1, MTRNR2L1, EEF1A1, PIP, FCGBP, WDR74, DMBT1, ZNF354B, IGHA1
Top 20 Transcribed Genes in the PARb
RN7SL1, AMY1A, HTN3, AMY1B, PRB1, MTRNR2L8, PRB3, STATH, PRB2, PRH1, PRH2, PRB4, HTN1, CA6, ENSG00000254144, PIGR, MTRNR2L1, PRR4, EEF1A1, RPPH1
Top 20 Transcribed Genes in the SMb
RN7SL1, STATH, HTN3, MTRNR2L8, HTN1, AMY1A, SMR3B, ZG16B, PIGR, PRH2, MTRNR2L1, ENSG00000254144, MUC7, CST4, RPPH1, ZFHX3, PRH1, AMY1B, CST1, EEF1A1
Additional Highly Transcribed Genes of Reported Functional Relevance in Gland Development, Physiology, or Pathologyc that Show Salivary-Gland-Type-Specific Expression
KLK1, LRP1B, MUCL1, CNTN5, SPP1, LRP2, EDN3, AGR2, TFF1, GALNT12, GALNT13, FSTL1, COL3A1, SPARC, PLXND1, POSTN
Additional Highly Transcribed Genes of Reported Functional Relevancec Coding for Non-Secreted Protein Products
RDH11, MAOB, FEZF2, LIM1XB, SLC5A5, DNER, PGR, ABCC1, GALNT13, NKX2-3, MCFD2, TCN1, FURIN
Top 10 Proteins Abundantly Found in Whole-Mouth Saliva that Likely Originate from Extrinsic Sources Such as Blood Plasma or Epithelial Linings of the Oral Cavity
ALB, IGHG2, AZGP1, IGHG1, ACTG1, IGKV3-20, IGKV4-1, IGKV4-5, S100A9, KRT1
Top 10 Transcribed TF Genesa in Salivary Glands
ZFHX3, ZNF354B, LTF, XBP1, TFCP2L1, EHF, FEZF2, SON, NFIB, FOXO3, JUN, ETV1, FOS
Additional Highly Transcribed TF Genes of Reported Functional Relevancec in Gland Development, Physiology, or Pathology
NKX3-1, BHLHA15, FOXA1, NKX2-3, HEY1, YAP1, TP63, SOX2, SOX2, SOX9, SOX10, FOXC1, FOXD3, CBX2, SOX11, ZBTB16, KLF9
a

Listed are the top 10 genes expressed in each major gland type. Because some of these genes overlap, the total of genes listed here is lower than 30. For a more systematic look into their expression in salivary glands, see Tables S2 and S4.

b

Underlined gene names designate those that are predominantly expressed in the respective gland category (log2 fold change > 2).

c

A more detailed description of these genes, including references, is provided in the main text.