Table 2. Electrical and mechanical nociceptive thresholds (ENT and MNT, respectively) and changes in mechanical nociceptive thresholds after application of a conditioning stimulus (ΔMNT) in dogs with naturally-occurring presumptive neuropathic pain before and after each treatment period.
ENT (mA) | MNT (N) | ΔMNT (N) | |
---|---|---|---|
Baseline | 49.5 ± 3.4 (n = 29) | 10.2 ± 0.5 (n = 29) | - 0.1 ± 0.6 (n = 27) |
Placebo | 42.3 ± 3.4 (n = 28) | 10.3 ± 0.5 (n = 28) | - 0.9 ± 0.6 (n = 26) |
Gabapentin | 38.3 ± 3.4 (n = 28) | 10.1 ± 0.5 (n = 28) | 0.8 ± 0.6 (n = 26) |
Gabapentin-meloxicam | 39.7 ± 3.4 (n = 28) | 10.3 ± 0.5 (n = 28) | 0.5 ± 0.6 (n = 26) |
Data shown as mean ± SEM after a mixed linear model to analyze ENT, MNT and ΔMNT with treatment as the main effect and sex, age and body weight as covariates.