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. 2020 Nov 26;12(11):e11714. doi: 10.7759/cureus.11714

Table 2. Toxicities Reported with Treatment.

R-CHOP, Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone.

CTCAE, Common Terminology Criteria for Adverse Events.

DA-REPOCH, Dose-adjusted rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin.

All toxicities reported in our patient population are listed. Toxicities are graded according to CTCAE version 5.

R-CHOP  CTCAE v5 any grade CTCAE v5 Grade 3 or higher
  No. (% of total population)
Any 10 (83%) 6 (50%)
Fatigue 6 (50%) 2 (17%)
Peripheral motor neuropathy 3 (25%) 0 (0%)
Heart failure 2 (17%) 2 (17%)
Febrile neutropenia 3 (25%) 3 (25%)
Lung infection 1 (8%) 1 (8%)
Rash 2 (17%) 0 (0%)
Thromboembolic event 1 (8%) 1 (8%)
Sepsis 1 (8%) 1 (8%)
Nausea and vomiting 1 (8%) 1 (8%)
Death 1 (8%) 1 (8%)
DA-REPOCH    
Any 7 (78%) 3 (33%)
Fatigue 4 (44%) 0 (0%)
Peripheral motor neuropathy 1 (11%) 0 (0%)
Generalized muscle weakness 1 (11%) 1 (11%)
Mucositis 1 (11%) 1 (11%)
Nausea and vomiting 1 (11%) 1 (11%)
Death 0 (0%) 0 (0%)