TABLE 5.
Random effects meta-analyses of the efficacy (complete remission (CR)) and safety (early mortality (EM) and veno-occlusive disease (VOD)) of the 6 mg/m2 regimen of Mylotarg based on the proposed exact method and the SJ-LGT and SJ-ASIN methods. Presented are the 95% confidence intervals and corresponding lengths for each of the methods
| Study | CR | EM | VOD |
|---|---|---|---|
| K | 6 | 5 | 7 |
| Exact | 0.007–0.128 (0.121) | 0.049–0.340 (0.291) | 0.072–0.367 (0.295) |
| SJ-LGT | 0.027–0.185 (0.158) | 0.064–0.342 (0.279) | 0.112–0.421 (0.310) |
| SJ-ASIN | 0.003–0.076 (0.073) | 0.001–0.252 (0.251) | 0.012–0.306 (0.294) |
| FE | 0.004 – 0.121 (0.116) | 0.041–0.262 (0.221) | 0.105–0.350 (0.245) |