Table III.
Observations, events, person-years, rates, and HRs of atrial fibrillation or flutter for persons with hospital-diagnosed atopic dermatitis compared with a matched comparison cohort, Denmark, 1977-2013
| Category | Observations, n | Events, n | Person-years | Rate, per 100,000 population | Model 1, HR (95% CI)∗ | Model 2, HR (95% CI)† | Model 3, HR (95% CI)‡ |
|---|---|---|---|---|---|---|---|
| Overall | |||||||
| Comparators | 124,211 | 631 | 2,530,240 | 24.9 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 13,126 | 80 | 257,435 | 31.1 | 1.2 (1.0-1.6) | 1.2 (0.9-1.5) | 1.2 (0.9-1.5) |
| Sex | |||||||
| Male | |||||||
| Comparators | 54,024 | 402 | 1,188,398 | 33.8 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 5630 | 43 | 119,291 | 36.0 | 1.0 (0.7-1.4) | 1.0 (0.7-1.3) | 1.0 (0.7-1.4) |
| Female | |||||||
| Comparators | 70,187 | 229 | 1,341,842 | 17.1 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 7496 | 37 | 138,143 | 26.8 | 1.6 (1.1-2.3) | 1.6 (1.1-2.3) | 1.6 (1.1-2.3) |
| Age at start of follow-up | |||||||
| 0-19 years | |||||||
| Comparators | 64,274 | 190 | 1,716,596 | 11.1 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 6509 | 29 | 170,203 | 17.0 | 1.6 (1.1-2.4) | 1.6 (1.1-2.4) | 1.6 (1.1-2.4) |
| 20-39 years | |||||||
| Comparators | 47,165 | 253 | 698,660 | 36.2 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 5208 | 28 | 74,928 | 37.4 | 1.0 (0.7-1.6) | 1.0 (0.7-1.5) | 1.0 (0.7-1.5) |
| 40-63 years | |||||||
| Comparators | 12,772 | 188 | 114,984 | 163.5 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 1409 | 23 | 12,304 | 186.9 | 1.1 (0.7-1.8) | 1.1 (0.7-1.7) | 1.1 (0.7-1.7) |
| Severity | |||||||
| Moderate | |||||||
| Comparators | 76,169 | 300 | 911,576 | 32.9 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 8357 | 38 | 98,463 | 38.6 | 1.2 (0.8-1.7) | 1.1 (0.8-1.6) | 1.1 (0.8-1.6) |
| Severe | |||||||
| Comparators | 45,873 | 280 | 637,486 | 43.9 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 5023 | 39 | 69,348 | 56.2 | 1.3 (0.9-1.8) | 1.2 (0.9-1.8) | 1.3 (0.9-1.8) |
| Allergic asthma or rhinitis | |||||||
| No | |||||||
| Comparators | 94,260 | 435 | 1,669,224 | 26.1 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 9979 | 47 | 170,487 | 27.6 | 1.0 (0.8-1.4) | 1.0 (0.7-1.4) | 1.0 (0.7-1.4) |
| Yes | |||||||
| Comparators | 41,472 | 196 | 861,016 | 22.8 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 4347 | 33 | 86,948 | 38.0 | 1.7 (1.2-2.5) | 1.6 (1.1-2.4) | 1.7 (1.1-2.4) |
| No. atopic dermatitis contacts | |||||||
| 1 | |||||||
| Comparators | 124,211 | 417 | 1,787,221 | 23.3 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 13,126 | 45 | 182,210 | 24.7 | 1.0 (0.8-1.4) | 1.0 (0.8-1.4) | 1.0 (0.8-1.4) |
| 2-4 | |||||||
| Comparators | 40,452 | 162 | 619,928 | 26.1 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 4277 | 27 | 62,925 | 42.9 | 1.6 (1.1-2.5) | 1.6 (1.0-2.4) | 1.6 (1.0-2.4) |
| 5-7 | |||||||
| Comparators | 7653 | 37 | 79,909 | 46.3 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 806 | 3 | 7964 | 37.7 | 0.7 (0.2-2.4) | 0.8 (0.3-2.8) | 0.9 (0.3-2.8) |
| ≥8 | |||||||
| Comparators | 3052 | 15 | 43,182 | 34.7 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Atopic dermatitis | 327 | 5 | 4336 | 115.3 | 3.2 (1.1-8.8) | 3.9 (1.3-12.0) | 4.0 (1.3-12.6) |
CI, Confidence interval; HR, hazard ratio.
∗
Unadjusted, stratified by matched set to account for matching factors (birth year, sex, index date).
†
Additionally adjusted for atrial fibrillation risk factors at baseline: chronic obstructive pulmonary disease, cardiovascular disease, rheumatic disease, sleep apnea, hospital-diagnosed obesity, hyperthyroidism, chronic kidney disease, diabetes mellitus, and alcohol-related disease.
‡
Additionally adjusted for educational level (complete-case analysis).