Table IV.
Sensitivity analyses of atrial fibrillation or flutter for persons with hospital-diagnosed atopic dermatitis compared with a matched comparison cohort, Denmark, 1977-2013
| Characteristic | Sensitivity analysis 1∗ |
Sensitivity analysis 2† |
Sensitivity analysis 3‡ |
||||
|---|---|---|---|---|---|---|---|
| Model 2 | Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | |
| Overall | 1.0 (0.8-1.3) | 1.2 (1.0-1.6) | 1.2 (0.9-1.5) | 1.2 (0.9-1.5) | NA | NA | NA |
| Sex | |||||||
| Male | 0.9 (0.6-1.2) | 1.0 (0.7-1.4) | 1.0 (0.7-1.3) | 1.0 (0.7-1.3) | NA | NA | NA |
| Female | 1.5 (1.0-2.1) | 1.6 (1.1-2.3) | 1.6 (1.1-2.3) | 1.6 (1.1-2.3) | NA | NA | NA |
| Diagnosis age, y | |||||||
| 0-19 | 1.5 (1.0-2.4) | 1.5 (1.0-2.3) | 1.5 (1.0-2.3) | 1.5 (1.0-2.3) | NA | NA | NA |
| 20-39 | 0.9 (0.6-1.3) | 1.1 (0.7-1.6) | 1.0 (0.7-1.5) | 1.0 (0.7-1.6) | NA | NA | NA |
| 40-63 | 0.9 (0.6-1.5) | 1.1 (0.7-1.8) | 1.1 (0.7-1.7) | 1.1 (0.7-1.7) | NA | NA | NA |
| Severity | |||||||
| Moderate | 1.1 (0.7-1.5) | 1.2 (0.8-1.7) | 1.1 (0.8-1.6) | 1.1 (0.8-1.6) | 1.2 (0.9-1.7) | 1.2 (0.8-1.7) | 1.2 (0.8-1.7) |
| Severe | 1.1 (0.7-1.5) | 1.3 (0.9-1.8) | 1.2 (0.9-1.8) | 1.3 (0.9-1.8) | 1.2 (0.9-1.7) | 1.2 (0.9-1.7) | 1.2 (0.9-1.7) |
| Allergic asthma or rhinitis | |||||||
| No | 0.9 (0.7-1.2) | 1.0 (0.8-1.4) | 1.0 (0.7-1.4) | 1.0 (0.7-1.4) | NA | NA | NA |
| Yes | 1.4 (0.9-2.2) | 1.7 (1.1-2.4) | 1.6 (1.1-2.4) | 1.6 (1.1-2.4) | NA | NA | NA |
| No. atopic dermatitis of contacts | |||||||
| <2 | 0.9 (0.7-1.3) | 1.1 (0.8-1.5) | 1.0 (0.8-1.4) | 1.1 (0.8-1.4) | NA | NA | NA |
| 2-4 | 1.3 (0.8-2.0) | 1.6 (1.1-2.5) | 1.5 (1.0-2.4) | 1.5 (1.0-2.4) | NA | NA | NA |
| 5-7 | 1.1 (0.3-4.4) | 0.5 (0.1-2.1) | 0.6 (0.1-2.4) | 0.6 (0.1-2.5) | NA | NA | NA |
| ≥8 | 2.9 (0.6-14.1) | 3.2 (1.1-8.8) | 3.9 (1.3-12.0) | 4.0 (1.3-12.6) | NA | NA | NA |
Values are HR (95% CI). Models were based on a Cox regression model stratified by matched set to account for matching factors (birth year, sex, index date). Model 1 was unadjusted. Model 2 additionally adjusted for atrial fibrillation risk factors chronic obstructive pulmonary disease, cardiovascular disease, rheumatic disease, sleep apnea, hospital-diagnosed obesity, hyperthyroidism, chronic kidney disease, diabetes mellitus, and alcohol-related disease. Model 3 as additionally adjusted for educational level (complete-case analysis).
CI, Confidence interval; HR, hazard ratio; NA, not applicable.
Repeated model 2 with atrial fibrillation risk factors included as time-updated covariates (mediation analysis).
Repeated the main analyses with delayed entry until January 1, 1996, in all comparisons.
Repeated severity analyses adding phototherapy as another criterion for severe atopic dermatitis.