Author response image 1. Comparison of five individual runs of Kilosort2 on the simulated Neuropixels recording.

The top shows the proportions of units from each sorting found in k other sortings. Below these units are split according to false and true positive units after comparison to the ground-truth data. While a sizable fraction of false positive units are unique to each run of the sorter, many are identical in all sortings, indicating that variability in multiple sorter outputs cannot be used to reliably separate false and true positive units.