Table 5.
GI50 Values for Compounds 1–10.a
| compound | cell line | ||
|---|---|---|---|
| MDA-MB-453 | SUM-185PE | MDA-MB-231 | |
| 1 | 5.4 ± 0.9 | 3.9 ± 0.8 | >100 |
| 2 | 3.5 ± 0.4 | 2.1 ± 0.8 | >100 |
| 3 | 3.3 ± 2.2 | 2.1 ± 0.5 | >100 |
| 4 | 3.7 ± 0.3 | 2.8 ± 0.6 | >100 |
| 5 | 3.6 ± 0.5 | 8.0 ± 5.1 | >100 |
| 6 | 2.5 ± 0.6 | 1.5 ± 0.1 | >100 |
| 7 | 4.0 ± 0.7 | 2.2 ± 0.7 | >100 |
| 8 | 7.9 ± 1.4 | 4.4 ± 0.7 | >100 |
| 9 | 2.6 ± 0.6 | 2.0 ± 0.2 | >100 |
| 10 | 2.3 ± 0.3 | 1.4 ± 0.2 | >100 |
| Rapamycin | 0.05 ± 0.04 | 0.04 ± 0.01 | >100 |
Concentrations (nM) that inhibit growth by 50%, n = 3 ± SD.