Table 2.
Univariate and multivariate cox regression analysis of overall survival (OS) in the training cohort.
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (y) | ||||||
| <48 | Reference | Reference | ||||
| 48–71 | 6.965 | 3.363–14.425 | ≤0.001∗ | 7.635 | 3.675–15.863 | ≤0.001∗ |
| >71 | 21.564 | 10.108–46.003 | ≤0.001∗ | 22.406 | 10.384–48.346 | ≤0.001∗ |
|
| ||||||
| Race | ||||||
| Black | Reference | |||||
| White | 0.764 | 0.421–1.388 | 0.377 | — | — | — |
| Others | 0.574 | 0.215–1.531 | 0.268 | — | — | — |
|
| ||||||
| Sex | ||||||
| Male | Reference | |||||
| Female | 0.571 | 0.402–0.811 | 0.002∗ | — | — | — |
|
| ||||||
| Number of nodules | ||||||
| Solitary | Reference | |||||
| Multiple | 0.620 | 0.410–0.939 | 0.024∗ | — | — | — |
|
| ||||||
| Tumor size(mm) | ||||||
| <20 | Reference | Reference | ||||
| 20–40 | 2.429 | 1.512–3.902 | ≤0.001∗ | 2.369 | 1.468–3.824 | ≤0.001∗ |
| >40 | 5.347 | 3.338–8.567 | ≤0.001∗ | 3.178 | 1.948–5.186 | ≤0.001∗ |
|
| ||||||
| T | ||||||
| T1a | Reference | |||||
| T1b | 1.362 | 0.597–3.106 | 0.463 | — | — | — |
| T2 | 2.050 | 0.976–4.309 | 0.058 | — | — | — |
| T3a | 3.505 | 1.659–7.404 | ≤0.001∗ | — | — | — |
| T3b | 4.787 | 2.337–9.808 | ≤0.001∗ | — | — | — |
| T4a | 9.006 | 4.236–19.148 | ≤0.001∗ | — | — | — |
| T4b | 6.743 | 2.736–16.615 | ≤0.001∗ | — | — | — |
|
| ||||||
| N | ||||||
| N0 | Reference | |||||
| N1a | 2.452 | 1.500–4.007 | ≤0.001∗ | — | — | — |
| N1b | 3.017 | 1.966–4.628 | ≤0.001∗ | — | — | — |
|
| ||||||
| M | ||||||
| M0 | Reference | Reference | ||||
| M1 | 6.117 | 3.984–9.392 | ≤0.001∗ | 3.936 | 2.488–6.227 | ≤0.001∗ |
|
| ||||||
| Number of removal LNs | ||||||
| 1–3 | Reference | |||||
| ≥4 | 1.117 | 0.709–1.762 | 0.632 | — | — | — |
|
| ||||||
| Total LNs | ||||||
| 0–11 | Reference | |||||
| 12–32 | 1.268 | 0.820–1.960 | 0.285 | — | — | — |
| 33–90 | 1.645 | 1.088–2.486 | 0.018∗ | — | — | — |
|
| ||||||
| pLNs | ||||||
| 0 | Reference | |||||
| 1–16 | 2.357 | 1.551–3.584 | ≤0.001∗ | — | — | — |
| 17–63 | 4.246 | 2.557–7.050 | ≤0.001∗ | — | — | — |
|
| ||||||
| LNR | ||||||
| <19.00% | Reference | Reference | ||||
| 19.00%–49.00% | 2.092 | 1.326–3.301 | 0.002∗ | 1.603 | 1.006–2.554 | 0.047∗ |
| >49.00% | 4.441 | 2.966–6.649 | ≤0.001∗ | 3.006 | 1.974–4.577 | ≤0.001∗ |
HR, hazard ratio; CI, confidence interval; ∗means P < 0.05.