Table 3.
Univariate and multivariate cox regression analysis of cancer-specific survival (CSS) in the training cohort.
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (y) | ||||||
| <48 | Reference | |||||
| 48–71 | 4.017 | 1.685–9.557 | 0.002∗ | 4.967 | 2.058–11.992 | ≤0.001∗ |
| >71 | 10.827 | 4.223–27.761 | ≤0.001∗ | 13.397 | 5.004–35.863 | ≤0.001∗ |
|
| ||||||
| Race | ||||||
| Black | Reference | |||||
| White | 0.843 | 0.336–2.115 | 0.715 | — | — | — |
| Others | 0.231 | 0.027–1.975 | 0.181 | — | — | — |
|
| ||||||
| Sex | ||||||
| Male | Reference | |||||
| Female | 0.573 | 0.337–0.973 | 0.039∗ | — | — | — |
|
| ||||||
| Number of nodules | ||||||
| Solitary | Reference | |||||
| Multiple | 0.843 | 0.472–1.507 | 0.565 | — | — | — |
|
| ||||||
| Tumor size (mm) | ||||||
| <20 | Reference | |||||
| 20–40 | 5.022 | 2.053–12.287 | ≤0.001∗ | 4.476 | 1.813–11.048 | ≤0.001∗ |
| >40 | 11.455 | 4.712–27.846 | ≤0.001∗ | 5.558 | 2.223–13.895 | ≤0.001∗ |
|
| ||||||
| T | ||||||
| T1a | Reference | |||||
| T1b | 1.060 | 0.149–7.529 | 0.953 | — | — | — |
| T2 | 4.081 | 0.881–18.904 | 0.072 | — | — | — |
| T3a | 5.536 | 1.150–26.655 | 0.033∗ | — | — | — |
| T3b | 13.180 | 3.014–57.640 | ≤0.001∗ | — | — | — |
| T4a | 29.048 | 6.518–129.457 | ≤0.001∗ | — | — | — |
| T4b | 27.548 | 5.691–133.349 | ≤0.001∗ | — | — | — |
|
| ||||||
| N | ||||||
| N0 | Reference | |||||
| N1a | 5.847 | 2.388–14.313 | ≤0.001∗ | — | — | — |
| N1b | 7.443 | 3.236–17.122 | ≤0.001∗ | — | — | — |
|
| ||||||
| M | ||||||
| M0 | Reference | |||||
| M1 | 12.854 | 7.382–22.384 | ≤0.001∗ | 6.694 | 3.690–12.145 | ≤0.001∗ |
|
| ||||||
| Number of removal LNs | ||||||
| 1–3 | Reference | |||||
| ≥4 | 1.015 | 0.520–1.981 | 0.965 | — | — | — |
|
| ||||||
| Total LNs | ||||||
| 0–11 | Reference | |||||
| 12–32 | 1.295 | 0.665–2.518 | 0.447 | — | — | — |
| 33–90 | 1.79 | 0.958–3.343 | 0.068 | — | — | — |
|
| ||||||
| pLNs | ||||||
| 0 | Reference | |||||
| 1–16 | 5.737 | 2.506–13.131 | ≤0.001∗ | — | — | — |
| 17–63 | 11.917 | 4.823–29.444 | ≤0.001∗ | — | — | — |
|
| ||||||
| LNR | ||||||
| <19.00% | Reference | |||||
| 19.00%–49.00% | 4.536 | 2.117–9.720 | ≤0.001∗ | 3.287 | 1.493–7.235 | 0.003∗ |
| >49.00% | 9.875 | 4.868–20.034 | ≤0.001∗ | 5.874 | 2.794–12.352 | ≤0.001∗ |