Table 1.

The gout treatment drugs and their side effects.

Gout treatment options	Drugs	Effect	Doses (mg/day)	Side effects
Xanthine oxidase inhibitors	Allopurinol	Reduces the level of blood uric acid [9]	50–800 [9]	(i) Digestive disorders
				(ii) Hypersensitivity syndrome
				(iii) Hepatotoxicity
				(iv) Skin reactions [14]
	Febuxostat	Reduces the level of blood uric acid [9]	80–120 [9]	(i) Digestive disorders
				(ii) Headache
				(iii) Liver problems
				(iv) Rash in the skin [9]
Uricosuric agents	Probenecid	Inhibition of the uric acid reabsorption [15]	—	(i) Gastrointestinal tract irritation
				(ii) Anorexia
				(iii) Skin reactions [9]
	Benzbromarone		100	(i) Hepatotoxicity [16]
	Lesinurad	Inhibition of the uric acid reabsorption [17]		(i) Gastroesophageal reflux disease
				(ii) Headache
				(iii) Influenza associated with kidney failure [9]
	Losartan/fenofibrate	Lowering urate formation [18]
Uricases	Rasburicase	The recombinant form of uricases		(i) Infusion problems [9]
				(ii) Antibody formation [19]
				(iii) Anaphylaxis [9]