Table 4.
Bivariable and multivariate analysis output for children with nephrotic syndrome in comprehensive specialized hospitals of Tigray region, Northern Ethiopia, 2019 (N = 174).
| Outcome status | Crude HR (95% CI) | Adjusted HR (95% CI) | |||
|---|---|---|---|---|---|
| Covariates | Category | Relapsed | Censored | ||
|
| |||||
| Age (in years) | 1-3 | 9 | 14 | 1.77 (0.78-4.00) | 2.24 (0.86-5.83) |
| 4-6 | 8 | 28 | 0.84 (0.36- 1.93) | 2.65 (0.99-7.11) | |
| 7-9 | 24 | 32 | 1.52 (0.83-2.79) | 1.33 (0.66-2.68) | |
| >9 | 21 | 38 | — | — | |
|
| |||||
| Residence | Urban | 51 | 7 | — | — |
| Rural | 123 | 55 | 2.9 (1.30-6.40) | 4 (1.49-10.76)∗ | |
|
| |||||
| History of allergy | Yes | 29 | 20 | 0.39 (0.22- 0.68) | 1.18 (0.61-2.28) |
| No | 145 | 42 | — | — | |
|
| |||||
| Time to achieve remission (days) | 0-7 | 19 | 4 | — | — |
| 8-14 | 80 | 21 | 1.63 (0.96-2.78) | 0.90 (0.27-2.99) | |
| >14 | 75 | 37 | 0.74 (0.37-1.48) | 1.18 (0.37-3.76) | |
|
| |||||
| Duration of treatment | <8 weeks | 39 | 16 | 0.65 (0.36-1.18) | 0.74 (0 .37-1.50) |
| ≥8 weeks | 135 | 46 | — | — | |
|
| |||||
| Albumin (g/dL) | ≤1.5 | 43 | 34 | 4.14 (2.44-7.00) | 3.51 (1.81-6.80)∗ |
| >1.5 | 131 | 28 | — | — | |
|
| |||||
| TGD | Normal | 43 | 5 | — | — |
| Borderline | 95 | 28 | 4.6 (1.38-15.28) | 1.66 (0.53-5.2) | |
| High | 36 | 29 | 9.78 (2.94-32.55) | 3.37 (1.04-10.9)∗ | |
|
| |||||
| Nutrition | Normal | 128 | 30 | — | — |
| Malnourished | 46 | 32 | 3.39 (2.01-5.71) | 3.44 (1.78-6.65)∗ | |
Note: ∗significant at 5% level of significance. Abbreviations: HR: hazard ratio; CI: confidence interval; g/dl: grams per deciliter; TGD: triglyceride.