(b).
| Intervention (mean) | Recurrence | Refractory | AEs | Use of concurrent (anti-TNF) |
|---|---|---|---|---|
| Fixed cell dose | 7 months without recurrence | Yes | Yes | |
| First: 2 × 107 MSCs | ||||
| Second: 4 × 107 MSCs | ||||
| Fixed cell dose | Two completely healed patients were followed up for 4 years without recurrence | Yes | Yes | |
| First: 2 × 107 MSCs | ||||
| Second: 4 × 107 MSCs | ||||
| Fixed cell dose | Unknown | Yes | No | |
| First: 2 × 107 MSCs | ||||
| Second: 4 × 107 MSCs | ||||
| Fixed cell dose | 24 w without recurrence | Yes | Yes | |
| A: 1 × 107 MSCs | ||||
| B: 3 × 107 MSCs | ||||
| C: 9 × 107 MSCs | ||||
| Fixed cell dose | Being follow-up | Yes | 68/103 in MSCs vs. 66/102 in placebo at 24 w | Yes |
| 12 × 107 MSCs | ||||
| Fixed cell dose | Being follow-up | Yes | 79/103 in MSCs vs. 74/102 in placebo at 52 w | Yes |
| 12 × 107 MSCs | ||||
| Fixed cell dose | Recurrence of the fistula was observed at 2-year follow-up in eight previously cured patients | Unknown | 7/23 MSCs+fibrin glue vs. 9/21 fibrin glue | No |
| First: 10 × 107 MSCs | ||||
| Second: 10 × 107 MSCs |