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. Author manuscript; available in PMC: 2021 Feb 26.
Published in final edited form as: Sci Transl Med. 2020 Aug 26;12(558):eaaz8664. doi: 10.1126/scitranslmed.aaz8664

Fig. 4. HUMBLE cell transplantation results in long-term metabolic benefits in mice.

Fig. 4.

(A) Schematic protocol for long-term transplantation of white control, HUMBLE or brown control preadipocytes into nude mice. (B) Body weight (BW) change in mice over 12 weeks after transplantation with white control, HUMBLE or brown control cells; n = 8 mice per group. (C to E) GTT in mice 4 weeks (C), 8 weeks (D), and 12 weeks (E) after transplantation with white control, HUMBLE or brown control cells; n = 8 mice per group. (F) Quantification of area under curve (AUC) in GTT after 4, 8, or 12 weeks of transplantation. (G to I) Representative images (upper) and quantification (lower) of UCP1 luciferase reporter activity by IVIS in mice transplanted with white control, HUMBLE, or brown control 4 weeks (G), 8 weeks (H) and 12 weeks (I) after transplantation; n = 8 mice per group. In all charts, data are presented as means ± s.e.m.; *p < 0.05; **p < 0.01; ***p < 0.001.