Fig. 1.

Overview on scientific publications using Caenorhabditis elegans for anthelmintic research.

The bar plot presents an overview of scientific studies that used the free-living model nematode C. elegans for anthelmintic research, sorted by the year of publication (1975–2019). Abstracts of relevant publications were collected by an automated literature search using the bibliographic databases CAB Direct (www.cabdirect.org), provided by Centre for Agriculture and Bioscience International (CABI), and EMBASE (www.emabse.com). For initial abstract extraction, terms were used that combined “C. elegans” with relevant key words, including “anthelmintic drugs”, “nematode parasite species” or “anthelmintic resistance”. The data set was manually curated to obtain a final number of 475 abstracts. For this final selection, publications were considered that included the experimental usage of C. elegans for anthelmintic drug discovery, target characterization, and mode of resistance elucidation. Moreover, selected review articles have a focus on different aspects of C. elegans in anthelmintic research. All selected abstracts are listed in Sup Table 1.