Table 1.

Examples for major anthelmintic drug targets identified by mutant screens in C. elegans.

Drug/drug class	Major C. elegans target gene(s)	Protein family	Genetic screen
Benzimidazole	ben-1	beta-tubulin	Driscoll et al. (1989)
Macrocyclic lactones	avr-14	GluCl subunit	Dent et al. (2000)
Macrocyclic lactones	avr-15	GluCl subunit	Dent et al. (2000)
Macrocyclic lactones	glc-1	GluCl subunit	Dent et al. (2000)
Imidazothiazoles	lev-1	nAChR subunit	Lewis et al. (1980), Fleming et al. (1997)
Imidazothiazoles	lev-8	nAChR subunit	Lewis et al. (1980), Towers et al. (2005)
Imidazothiazoles	unc-29	nAChR subunit	Brenner (1974), Fleming et al. (1997)
Imidazothiazoles	unc-38	nAChR subunit	Brenner (1974), Fleming et al. (1997)
Imidazothiazoles	unc-63	nAChR subunit	Brenner (1974), Culetto et al. (2004)
AADs	acr-23	nAChR subunit	Kaminsky et al. (2008a)
AADs	acr-20	nAChR subunit	Baur et al. (2015)
Cyclooctadepsipeptides	slo-1	voltage-gated potassium channel	Guest et al. (2007)

Abbreviations - GluCl: glutamate-gated chloride channel; nAChR: nicotinic acetylcholine receptor; AADs: amino-acetonitrile derivatives.