Table 2.
Examples for anthelmintic drug target genes characterized in the C. elegans expression system.
| Expressed parasite target genes | Drug/drug class | Findings | Reference |
|---|---|---|---|
| tbb-iso-1 (H. contortus) | Benzimidazoles | Characterization of putative benzimidazole resistance alleles using C. elegans as a heterologous expression system. | Kwa et al. (1995) |
| Glucl_alpha3 (H. contortus) | Ivermectin | Expression of glucl_alpha3 restores motor movement in C. elegans avr-14 knock out when expressed under control of the avr-14 promoter | Cook et al. (2006) |
| avr-14b, glc-2, glc-5, glc-6 (H. contortus) | Ivermectin | Expression of H. contortus GluCl subunits rescued ivermectin sensitivity in a highly resistant triple mutant C. elegans strain (DA1316) | Glendinning et al. (2011) |
| slo-1 (A. caninum, C. oncophora) | Emodepside | Expression of A. caninum and C. oncophora slo-1 in the emodepside-resistant C. elegans slo-1 knock-out strain rescued emodepside sensitivity. | Welz et al. (2011) |
| acr-26, acr-27 (H. contortus, P. equorum) | Morantel, pyrantel | Heterologous expression of the H. contortus and P. equorum receptors drastically increased C. elegans sensitivity to morantel and pyrantel | Courtot et al. (2015) |
| unc-29, unc-38 (H. contortus), | Levamisole | H. contortus and A. suum unc-38 and unc-29 were able to (partially) rescue the levamisole-sensitivity and locomotion defects when expressed in C. elegans null mutant strains | Sloan et al. (2015) |
| unc-29 (A. suum) | |||
| Acr-8 (H. contortus) | Levamisole, pyrantel | Expression of H. contortus acr-8 in the C. elegans lev-8 null mutant rescued levamisole and pyrantel sensitivities | Blanchard et al. (2018) |